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Nutraceutical Applications of Saberry® :
  Saberry® has significant potential in the following applications:
  Antioxidant Potential:

Saberry® exhibits significant antioxidant activity and is “ORAC Dense”. Literature reports validate the antioxidant potential of Amla in vivo. Amla extract inhibits radiation‐induced lipid peroxidation (LPO) in microsomes, and protects SOD in mitochondria.

For the LPO experiment, Amla extract was added in aqueous solution. The extent of LPO was measured in terms of thiobarbituric acid reactive substances. It was observed that Amla extract acts as a very good antioxidant against γ-radiation induced LPO. Similarly, Amla extract was found to inhibit the damage to antioxidant enzyme SOD in rat liver microsomes. The antioxidant activity of the Amla extract was found to be both dose-and concentration-dependent. The authors concluded that Amla extract being water-soluble, may scavenge the free radicals responsible for initiating lipid peroxidation.

   
  Digestive Aid:

Amla fruit has been traditionally used as a digestive aid in India. It also forms an important constituent of Triphala – an ayurvedic preparation recognized for its role in supporting digestive functions.

Amla is known to improve the stimulation of gastric juices and also support detoxification.
Amla is also reported to have antibacterial and astringent properties that potentially support the management of infections and help in the healing of ulcers.

Rafatullah (2002) demonstrated the gastroprotective effects of Amla in vivo in rats. Amla extract was found to possess antisecretory, antiulcer, and cytoprotective properties.

   
  Anti-diabetic Potential:

Suryanaraya et al (2004) investigated the beneficial role of Amla extract in diabetes induced complications. Aldose reductase (AR) has been a drug target because of its involvement in the development of secondary complications of diabetes, including cataract. Amla extract inhibited rat lens AR and recombinant human AR with IC50 values 0.72 and 0.88 mg/ml respectively.

In-house studies on β-glucogallin showed an IC50 value of 53.7 µg/ml for the inhibition of aldose reductase, in rat lens.

Rao et al (2005) reported the efficacy of Amla extract in relieving oxidative stress, and improving glucose metabolism in diabetic rats. Yokozawa et al (2007) demonstrated that administration of Amla extract helps in the management of age-related renal dysfunction in aging animal models, through inhibiting oxidative stress and inflammatory pathways. Renal dysfunction is a common secondary complication in diabetes.

   
  Hepatoprotectant Potential Of Amla

Amla is used in Indian system of medicine for the treatment of liver ailments. Emblica officinalis has the potential to suppress carcinogen‐induced response in rat liver.

The research conducted at Amala Cancer Research Centre in Kerala, India, has found that an extract of Phyllanthus emblica significantly inhibited hepato‐carcinogenesis induced by N-nitrosodiethylamine (NDEA) in experimental animals.

Fibrosis of the liver is a state of complicated end stage alteration of structure and function due to different etiologies. There is no established therapy, and the treatment options require long term administration of putative anti‐fibrotics which must be free of side effects.

Emblica officinalis (fruit) exract reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improvement in liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin in serum.

     
Dosage form and Suggested use level:
 

Saberry® can be used in the form of capsules, tablets or incorporated in functional foods

Saberry®, being water soluble, can also be conveniently incorporated into various beverages. Thus Saberry™ finds interesting applications in health and wellness beverages, citrus fruit juices, sports drinks etc.

Depending on the intended use, we suggest that Saberry® be used at levels ranging from 200 mg to 1000 mg per day in two divided doses.

Saberry® also finds interesting applications in

 
  • Fruit juices
  • Citrus-based beverages
  • Noodle flavor packs
  • Dusting flavors for products like chips, wafers, cashewnuts, peanuts etc.
     
  Formulary Example
 
Instant Iced Tea with Saberry™
Ingredients
Percentage
     Sweetener
0.24/90.00
     Instant tea
1.50
     Green tea
0.10
     Maltodextrin
4.10
     Citric acid
0.70
     Malic acid
0.50
     Tri-sodium citrate
0.30
     Flavour
0.30
     Saberry®
2.50
Iced Tea with Saberry
 
Add 8 gms in 100ml chilled water and serve. Each serving provides 200 mg of Saberry® extract.
 
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